According to the new market research report “Protein Expression Market by Type (E.Coli, Mammalian, CHO, HEK 293, Insect, Pichia, Cell-free), Products (Reagents, Vectors, Competent Cells, Instruments, Service), Application (Therapeutic, Industrial), End User, and Region – Global Forecast to 2027″, The global protein expression market is expected to reach USD 5.4 billion in 2027 from USD 2.9 billion in 2022 at a CAGR of 13.3% during the forecast period.
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Factors such as growing pharmaceutical and biotechnology industries, rising adoption of recombinant-based protein expression as well as increasing public and private support through initiatives and funding are favouring the growth of this market. However, the high cost of protein expression reagents and instruments is likely to restrain the growth of this market.
Based on system type, the protein expression market is segmented into mammalian cell expression systems, prokaryotic expression systems, insect cell expression systems, yeast expression systems, cell-free expression systems, and algal-based expression systems. The mammalian cell expression systems segment accounted for the largest share of the global protein expression market in 2021.
Based on application, the protein expression market is segmented into therapeutic, research and industrial applications. In 2021, the therapeutic applications segment accounted for the largest share of the global protein expression market. Factors such as an increase in protein-based research and the rising prevalence of chronic diseases across the globe contribute to the large share of this market.
Based on product & service, the protein expression market is segmented into reagents, expression vectors, competent cells, instruments, and services. The reagents segment accounted for the largest share of the global protein expression market in 2021. Factors such as the increasing research activities in the field of protein expression as well as the large-scale production of antibodies and vaccines are responsible for large share of this market.
Based on end users, the protein expression market is segmented into pharmaceutical and biotechnology companies, contract research organizations and contract development and manufacturing organizations (CROs and CDMOs), academic research institutes, and other end users. In 2021, the pharmaceutical and biotechnology companies segment accounted for the largest share of the global protein expression market due to an increase in protein research to understand biological systems and the rising production of recombinant therapeutic proteins for disease treatment.
Geographical Growth Scenario:
Based on region, the protein expression market is segmented into North America, Europe, Asia Pacific, Rest of the world (Latin America, and the Middle East & Africa). In 2021, North America accounted for the largest share of the global protein expression market, followed by Europe. Factors such as growth in the biotechnology and pharmaceutical industries, the rising prevalence of chronic disorders, and an increase in protein-based therapeutics research investments in the region contribute to its large share. The APAC market is projected to grow at the highest CAGR during the forecast period.
Key Players:
Thermo Fisher Scientific, Inc (US), Merck KGaA (Germany), GenScript Biotech Corporation (US), Agilent Technologies, Inc. (US), Takara Bio, Inc. (Japan), Bio-Rad Laboratories, Inc. (US), Qiagen N.V (Netherlands), Charles River Laboratories, Inc. (US), Danaher Corporation (US), Sartorius AG (Germany), Corning Incorporated (US), FUJIFILM Irvine Scientific, Inc. (Japan), Lonza Group AG (Switzerland), Bioneer Corporation (South Korea), Promega Corporation (US), Oxford Expression Technologies Ltd. (UK), ProteoGenix (France), Abeomics, Inc. (US), New England Biolabs, Inc. (US), Promab Biotechnologies (US), Sino Biological, Inc. (China), Jena Bioscience (Germany), Lifesensors, Inc. (US), Leading biology, Inc. (US), and Peak Proteins (UK).
Recent Developments:
In June 2021, Thermo Fisher Scientific Inc. (US) and Advanced Electrophoresis Solutions Ltd. (AES) (Canada) signed an agreement to combine essential protein separation techniques with mass spectrometry (MS) to advance therapeutic protein development through streamlined characterization.
In June 2020, Lonza Group AG (Switzerland) launched GSv9, a chemically defined media and feeds platform specifically developed to enhance the performance of the GS Gene Expression System for optimized recombinant protein production.
The global protein expression market is expected to experience substantial growth in the coming years, projected to expand from $2.9 billion in 2022 to $5.4 billion by 2027 at a compound annual growth rate (CAGR) of 13.3%. This burgeoning market is driven by several key factors, including the increasing demand for protein biologics, particularly in the treatment of chronic diseases such as cancer, autoimmune disorders, and other serious conditions.
As the life science and biopharmaceutical industries continue to thrive, the focus on recombinant protein expression and the availability of investments for protein-based research are providing further impetus to the market’s growth. However, the high cost of protein expression reagents and instruments remains a restraining factor, potentially limiting adoption in certain areas.
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One of the notable trends shaping the market is the emergence of microfluidics, an advanced technique offering robust solutions for protein expression studies and analysis. Microfluidic technologies, such as droplet-based microfluidic (DBM) high-throughput screening and microfluidic antibody capture (MAC) chips, are enabling more efficient and precise evaluation of protein expression levels and protein modifications.
While the market faces challenges related to undesired post-translational modifications and the complexities of protein purification, the mammalian cell expression system segment continues to dominate, driven by its low cost and ease of use.
Geographically, North America currently leads the protein expression market, propelled by the region’s strong biotechnology and pharmaceutical industries, the prevalence of chronic disorders, and increased investments in protein-based therapeutics research.
Key players in the global protein expression market include Thermo Fisher Scientific, Merck KGaA, GenScript Biotech Corporation, Agilent Technologies, Danaher Corporation, Sartorius AG, Takara Bio, Bio-Rad Laboratories, Lonza Group AG, Promega Corporation, New England Biolabs, and Oxford Expression Technologies Ltd.
As the demand for protein biologics continues to surge and technological advancements unlock new possibilities, the protein expression market is poised for sustained growth, driving innovation and propelling the development of groundbreaking therapeutics.
Based on geography, the global protein expression market is segmented into Asia, Europe, North America, and Rest of the World (RoW). Of these, the Asian segment that includes the regional segments of China, India, Japan, and Rest of Asia (RoA) is expected to grow at the highest CAGR between 2013 and 2018. The growth in the Asian economies, particularly in China and India along with the increasing investments in biotechnology in Asia will be the major drivers for growth in the Asian protein expression market. In addition, the Asian region has witnessed an upward trend in the proteomics market over the past few years as many North American and European pharmaceutical drug manufacturers find it cost-effective to outsource their proteomics-based work to Asian manufacturers or set up their own manufacturing facilities in the Asian countries.
Thus, on account of the rise in demand of biologics, therapeutic proteins emerge as a lucrative revenue pocket. The demand for therapeutic proteins will handsomely reward investments made in the therapeutic protein industry. In the forecast period between 2013 and 2018, contract research organizations will provide generous returns on investments on account of the rising trend in outsourcing of research activities. Similarly, the economic developments in the Asian region will make the Asian countries one of the most lucrative revenue pockets in the global protein expression market. Investments made in the Asian proteomics industry will reap heavy dividends.