The Humanized Mouse and Rat Model Market has witnessed significant growth in recent years, propelled by advancements in biomedical research and the increasing demand for preclinical models that closely mimic human physiology. These models play a pivotal role in drug discovery, development, and testing, offering a more accurate representation of human responses to potential therapeutic interventions.


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One driving factor behind the expanding Humanized Mouse and Rat Model Market is the rising emphasis on personalized medicine. As researchers seek to develop treatments tailored to individual patient characteristics, the need for reliable preclinical models that can simulate human disease states becomes paramount. Humanized mice and rats, with their genetically modified structures to incorporate human genes or tissues, provide a more clinically relevant platform for studying disease mechanisms and testing potential treatments.


Global Humanized Mouse and Rat Model Market Segmentation

Humanized Mouse and Rat Model by Model Type: Market Size & Forecast 2023-2030

  • PDX (Patient-Derived Xenograft)
  • Knock-in/Knock-out
  • BAC (Bacterial Artificial Chromosome) Transgenic
  • Cytokine-Humanized
  • Immune-Humanized (liver, bone marrow, etc.)
  • Other

Humanized Mouse and Rat Model by Application: Market Size & Forecast 2023-2030

  • Oncology
  • Immunology & Inflammation
  • Infectious Diseases
  • Metabolic Diseases
  • CNS & Neurodegenerative Diseases
  • Drug Discovery & Development
  • Toxicology & Safety Testing
  • Other

Humanized Mouse and Rat Model by Technology: Market Size & Forecast 2023-2030

  • CRISPR-Cas9
  • Humanized Immune System Engineering (huMICE)
  • Microbiome Humanization
  • Organ-on-a-Chip
  • Other

Humanized Mouse and Rat Model by End User: Market Size & Forecast 2023-2030

  • Pharmaceutical & Biotechnology Companies
  • Contract Research Organizations (CROs)
  • Academic & Research Institutions
  • Government Agencies & Regulatory Bodies
  • Other

Humanized Mouse and Rat Model by Geography: Market Size & Forecast 2023-2030

  • North America (USA, Canada, Mexico)
  • Europe (Germany, UK, France, Russia, Italy, Rest of Europe)
  • Asia-Pacific (China, Japan, South Korea, India, Southeast Asia, Rest of Asia-Pacific)
  • South America (Brazil, Argentina, Columbia, Rest of South America)
  • Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Rest of MEA)

Major Players:

  • The Jackson Laboratory
  • Taconic Biosciences, Inc.
  • Charles River Laboratories International, Inc.
  • Janvier Labs
  • genOway S.A.
  • Ingenious Targeting Laboratory, Inc.
  • Horizon Discovery Group plc
  • Hera BioLabs, Inc.
  • Trans Genic Inc.
  • Crown Bioscience Inc.
  • Envigo RMS LLC
  • Biomere
  • Harbour Antibodies BV
  • Champions Oncology, Inc.
  • Vitalstar Biotechnology Co., Ltd.
  • Axenis S.A.S.
  • Biocytogen LLC
  • Beijing Vitalstar Biotechnology Co., Ltd.
  • SAGE Labs, Inc. (part of Horizon Discovery Group plc)
  • InVivos Pte. Ltd.
  • Ozgene Pty Ltd.
  • Transposagen Biopharmaceuticals, Inc.
  • genoway (a Subsidiary of genOway S.A.)
  • Synthego Corporation


The pharmaceutical and biotechnology industries heavily rely on these models during the drug development process. Humanized mice and rats offer a closer approximation to human immune responses and toxicological effects, thereby reducing the gap between preclinical studies and human clinical trials. This alignment helps in predicting drug efficacy and potential side effects more accurately, contributing to a more efficient drug development pipeline.


Researchers are increasingly turning to humanized models to study complex diseases such as cancer, autoimmune disorders, and infectious diseases. The ability to graft human tissues or cells into these models enables the investigation of disease progression and therapeutic interventions in a manner closely resembling the human context. Consequently, the Humanized Mouse and Rat Model Market have become instrumental in advancing our understanding of disease biology and accelerating the development of targeted therapies.


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Moreover, the continuous refinement of gene-editing technologies has enhanced the precision and efficiency of creating humanized models. CRISPR/Cas9 and other gene-editing tools allow researchers to introduce specific genetic modifications with unprecedented accuracy, enabling the creation of more sophisticated and relevant models for a wide range of research applications.


As the demand for more translational and clinically relevant research models grows, the Humanized Mouse and Rat Model Market are expected to witness further expansion. The market’s evolution is also influenced by collaborations between research institutions, pharmaceutical companies, and model development companies. These collaborations aim to create customized models tailored to specific research needs, driving innovation and diversification within the market.


Table of Contents

  1. Executive summary

2.1               MARKET SCOPE

2.2               MARKET Definitions

  1. research methodology
  2. market outlook

4.1               Key Trends

4.2               GUIDELINES / REGULATIONS


4.4               MARKET DYNAMICS

4.4.1                   Drivers               Rising demand for personalized medicine               Ongoing support for cancer research               Growth of biotechnology and pharmaceutical industries

4.4.2                   Restraints               Expensive custom humanized models               Strict regulations for ethical use of animal models in research

4.4.3                   Opportunities               Development of CRISPR as a potent tool for biomedical research

4.4.4                   Challenges               Alternatives available for using animals in testing

4.5               PriCing Analysis

4.6               PORTER’S FIVE FORCE MODEL

4.6.1                   Threat of new entrants

4.6.2                   Threat of substitute

4.6.3                   Bargaining power of suppliers

4.6.4                   Bargaining power of buyers

4.6.5                   Intensity of competitive rivalry


5.1               INTRODUCTION

5.2               MARKET SHARE ANALYSIS

5.3               Genetic models

5.4               cell-based models

5.4.1                   CD34

5.4.2                   BLT

5.4.3                   PMC

5.5               RAT MODELS

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